Mufflers are critical on two strokes because expansion chambers are sonically tuned - but they only serve to deaden sound on a four stroke - UNLESS they are a reverse cone megapahone type which accelerates cylinder scavenging . Once the gas is out of the cylinder - it's out for good on the 4's whereas 2's use back pressure to shove extra charge back in .
Look at speedway bikes - they used to run straight pipes but now they have to run a HUGE muffler because of noise laws . Drag cars run NO mufflers and they are built for maximum torque and HP and neither do a lot of prop aeroplanes which need maximum torque and HP .
Most people get their back pressure for 4 strokes ideas because they've altered a stock pipe without retuning the carb - which was already detuned to work with the back pressure of the stock pipe . If the head hasn't been ported , then the diameter of the header pipe on any replacement pipe shouldn't be much larger than stock . But then again - if you look at the '73 to '76 model XR75's - they had a big header pipe as stock - then in later years Honda made them smaller - coupled with a performance drop to go with it .